首个人体研究显示：类淋巴系统功能改变介导阿尔茨海默病的认知功能障碍!

在区域淀粉样蛋白和tau蛋白沉积和GMV比率之间的ALPS指数中介分析中，总效应在所有脑区均显著，但ALPS 指数仅在顶叶和颞叶中显示出中介效应（Pm=13.71%-17.86%）。

总的来说，这是一项探索性的研究，首次在人类中探讨了类淋巴系统功能在淀粉样蛋白和tau蛋白的沉积与认知功能障碍之间的作用，研究结果显示出ALPS 指数在淀粉样蛋白和 tau蛋白沉积与认知功能障碍之间起到重要中介效应，这再一次表明类淋巴系统功能障碍在AD的发病中起到一定的作用。同时，ALPS指数还可作为AD患者疾病进展或治疗评估的生物标志物。

参考文献

1. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SAet al: A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012, 4(147):147ra111.

2. Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KSet al: Structural and functional features of central nervous system lymphatic vessels. Nature 2015, 523(7560):337-341.

3. Mestre H, Mori Y, Nedergaard M: The Brain s Glymphatic System: Current Controversies. Trends Neurosci 2020, 43(7):458-466.

4. Harrison IF, Ismail O, Machhada A, Colgan N, Ohene Y, Nahavandi P, Ahmed Z, Fisher A, Meftah S, Murray TKet al: Impaired glymphatic function and clearance of tau in an Alzheimer s disease model. Brain 2020, 143(8):2576-2593.

5. Nedergaard M, Goldman SA: Glymphatic failure as a final common pathway to dementia. Science 2020, 370(6512):50-56.

6. Hsu JL, Wei YC, Toh CH, Hsiao IT, Lin KJ, Yen TC, Liao MF, Ro LS: Magnetic Resonance Images Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction in Alzheimer Disease. Ann Neurol 2022.