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《自然》子刊:军科院团队发现间歇性禁食改善阿尔茨海默病的机制!

总的来说,这项研究发现,间歇性禁食可以通过改变AD模式小鼠肠道菌群组成来改变代谢,从而抑制AD进展,而直接补充代谢物Sar或DMG可以模拟间歇性禁食的保护效应。

参考文献:

1. Pan R-Y, Zhang J, Wang J, et al. Intermittent fasting protects against Alzheimer s disease in mice by altering metabolism through remodeling of the gut microbiota. Nat Aging. 2022;2(11):1024-1039. doi:10.1038/s43587-022-00311-y

2. Halagappa VKM, Guo Z, Pearson M, et al. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer s disease. Neurobiol Dis. 2007;26(1):212-220. doi:10.1016/j.nbd.2006.12.019

3. Zhang J, Zhan Z, Li X, et al. Intermittent Fasting Protects against Alzheimer s Disease Possible through Restoring Aquaporin-4 Polarity. Front Mol Neurosci. 2017;10:395. doi:10.3389/fnmol.2017.00395

4. Shin BK, Kang S, Kim DS, Park S. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer s disease-induced estrogen deficient rats. Exp Biol Med (Maywood). 2018;243(4):334-343. doi:10.1177/1535370217751610

5. Liu Y, Cheng A, Li Y-J, et al. SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice. Nat Commun. 2019;10(1):1886. doi:10.1038/s41467-019-09897-1

6. Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. Front Microbiol. 2018;9:757. doi:10.3389/fmicb.2018.00757

7. Chan M-H, Chung S-S, Stoker AK, Markou A, Chen H-H. Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice. Toxicol Appl Pharmacol. 2012;265(2):158-165. doi:10.1016/j.taap.2012.10.004

8. Hsieh C-P, Chen H, Chan M-H, Chen L, Chen H-H. N,N-dimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice. Toxicology. 2020;446:152613. doi:10.1016/j.tox.2020.152613

9. Nicolas S, Nolan YM. Intermittent fasting to slow down Alzheimer s disease. 2022;2(November):982-983. doi:10.1038/s43587-022-00320-x

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