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一文了解小核酸抗体偶联药物(AOC)全球市场现状

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[3]. Victor Lehot, et al.Non-specific interactions of antibody-oligonucleotide conjugates with living cells.Sci Rep.2021 Mar 15;11(1):5881.doi: 10.1038/s41598-021-85352-w.

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[5]. Nicole B umer, et al.Antibody-coupled siRNA as an efficient method forin vivomRNA knockdown.Nat Protoc.2016 Jan;11(1):22-36.doi: 10.1038/nprot.2015.137.

[6]. Hua Lu, et al.Site-specific antibody-polymer conjugates for siRNA delivery.JAm Chem Soc.2013 Sep 18;135(37):13885-91.doi: 10.1021/ja4059525.

[7]. Patrick J Kennedy, et al.Antibodies and associates: Partners in targeted drug delivery.Pharmacol Ther.2017 Sep;177:129-145.doi: 10.1016/j.pharmthera.2017.03.004.

[8]. Guizhi Zhu, et al.Aptamer-Drug Conjugates.Bioconjug Chem.2015 Nov 18;26(11):2186-97.doi: 10.1021/acs.bioconjchem.5b00291.

[9]. Tsukasa Sugo, et al.Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles.J Control Release.2016 Sep 10;237:1-13.doi: 10.1016/j.jconrel.2016.06.036.

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