《自然》子刊：疫苗接种也有良辰吉时？科学家首次揭示昼夜节律影响T细胞响应疫苗的机制，树突细胞的抗原处理功能是关键

这些结果揭示了生物钟对DC细胞线粒体代谢、形态以及伴随的抗原处理能力的昼夜节律具有调节作用。

最后，Curtis团队的研究还表明线粒体内钙离子水平的昼夜节律是导致线粒体形态变化的内在原因。受线粒体钙单向转运蛋白（MCU）复合体周期变化导致的钙离子水平昼夜节律影响，线粒体内钙调神经磷酸酶活性也呈现周期变化，而钙调神经磷酸酶正是影响线粒体形态的关键调节因子。

总的来说，本研究首次揭示了机体对疫苗接种存在昼夜变化的内在机制，其与树突细胞线粒体钙离子水平、形态和代谢功能受生物钟调控息息相关。

若能在人类中进行相关检测，Curtis团队的研究对今后疫苗接种时间的安排或具有重要的启示作用。

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